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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Johnson–Corey–Chaykovsky reaction ： ウィキペディア英語版 Johnson–Corey–Chaykovsky reaction The Johnson–Corey–Chaykovsky reaction (sometimes referred to as the Corey–Chaykovsky reaction or CCR) is a chemical reaction used in organic chemistry for the synthesis of epoxides, aziridines, and cyclopropanes. It was discovered in 1961 by A. William Johnson and developed significantly by E. J. Corey and Michael Chaykovsky. The reaction involves addition of a sulfur ylide to a ketone, aldehyde, imine, or enone to produce the corresponding 3-membered ring. The reaction is diastereoselective favoring ''trans'' substitution in the product regardless of the initial stereochemistry. The synthesis of epoxides via this method serves as an important retrosynthetic alternative to the traditional epoxidation reactions of olefins. The reaction is most often employed for epoxidation via methylene transfer, and to this end has been used in several notable total syntheses (See Synthesis of epoxides below). Additionally detailed below are the history, mechanism, scope, and enantioselective variants of the reaction. Several reviews have been published. ==History== The original publication by Johnson concerned the reaction of 9-dimethylsulfonium fluorenylide with substituted benzaldehyde derivatives. The attempted Wittig-like reaction failed and a benzalfluorene oxide was obtained instead, noting that "Reaction between the sulfur ylid and benzaldehydes did not afford benzalfluorenes as had the phosphorus and arsenic ylids." The subsequent development of (dimethyloxosulfaniumyl)methanide, (CH3)2SOCH2 and (dimethylsulfaniumyl)methanide, (CH3)2SCH2 (known as Corey–Chaykovsky reagents) by Corey and Chaykovsky as efficient methylene-transfer reagents established the reaction as a part of the organic canon. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Johnson–Corey–Chaykovsky reaction」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.